Reactome | ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA

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ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA Show undefined attributes

catalystActivity	[CatalystActivity:10798821] protein serine/threonine kinase activity of FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10798823
displayName	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
eventOf	[Pathway:R-GGA-6783310] Fanconi Anemia Pathway - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA - Homo sapiens
input	8 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-GGA-6788386] FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
output	8 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-GGA-176269] ATR:ATRIP [nucleoplasm] [Complex:R-GGA-6788398] p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] [Complex:R-GGA-5685169] p-RPA heterotrimer [nucleoplasm]
precedingEvent	[Reaction:R-GGA-6788385] The complex of ATR and ATRIP is recruited to ICL-DNA - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-6788392
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-6783310] Fanconi Anemia Pathway
(inferredTo)	[Reaction:R-HSA-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA

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