Reactome | Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE

authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
dbId	433819
displayName	Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
eventOf	[Pathway:R-GGA-433835] IKK related kinases bound to dsRNA:TLR3:TICAM1 activate IRF3 - Gallus gallus
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-433804] IKK epsilon is recruited to the Viral dsRNA:TLR3:TICAM1 complex - Gallus gallus [Reaction:R-GGA-433826] Phosphorylation of IRF3 by IKK epsilon(IKBKE) complexed with activated TLR3 - Gallus gallus [Reaction:R-GGA-434027] Dimerization of Phospho-IRF3 - Gallus gallus [Reaction:R-GGA-433967] Dimerized Phospho-IRF3 is Transported To The Nucleus - Gallus gallus
inferredFrom	[Pathway:R-HSA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Homo sapiens
isInDisease	false
isInferred	true
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:434145] Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity [LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-433819
summation	[Summation:433859] Embryonic fibroblast cells from TBK1-deficient mice show dec...
updateTrackers	[UpdateTracker:9786374] Update Tracker - [Pathway:433819] Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK - v49:[updateContainedRLE] [UpdateTracker:9789935] Update Tracker - [Pathway:433819] Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK - v36:[updateContainedRLE] [UpdateTracker:9846604] Update Tracker - [Pathway:433819] Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK - v84:[updateContainedRLE] [UpdateTracker:9789610] Update Tracker - [Pathway:433819] Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK - v37:[updateContainedRLE] [UpdateTracker:9788120] Update Tracker - [Pathway:433819] Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK - v43:[updateContainedRLE]

Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK Show undefined attributes

Referrals

(updatedInstance)	[UpdateTracker:9786374] Update Tracker - [Pathway:433819] Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK - v49:[updateContainedRLE] [UpdateTracker:9789935] Update Tracker - [Pathway:433819] Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK - v36:[updateContainedRLE] [UpdateTracker:9846604] Update Tracker - [Pathway:433819] Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK - v84:[updateContainedRLE] [UpdateTracker:9789610] Update Tracker - [Pathway:433819] Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK - v37:[updateContainedRLE] [UpdateTracker:9788120] Update Tracker - [Pathway:433819] Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK - v43:[updateContainedRLE]
(hasEvent)	[Pathway:R-GGA-433835] IKK related kinases bound to dsRNA:TLR3:TICAM1 activate IRF3
(inferredTo)	[Pathway:R-HSA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)