Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK

Stable Identifier
R-GGA-433819
Type
Pathway
Species
Gallus gallus
Related Species
Infectious bronchitis virus
ReviewStatus
5/5
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Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK
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Embryonic fibroblast cells from TBK1-deficient mice show decreased IRF3 activation and IFN induction by poly IC, while IKKi-deficient cells show normal IRF3 activation. However, residual activation of IRF3 in TBK1-deficient cells is totally abolished in TBK1 and IKKi double-deficient cells, indicating that the functions of TBK1 and IKKi are redundant in fibroblast cells.[Hemmi et al 2004].

It was also reported that IKKi directly phophorylates signal transducer and activator of transcription 1 (STAT1) [Tenoever et al 2007].

Chicken IKKi shows 68% and 62% identity to the human IKKi and human TBK1 respectively.

Literature References
PubMed ID Title Journal Year
15210742 The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection

Takeuchi, O, Hoshino, K, Sanjo, H, Takeda, K, Sato, S, Yamamoto, M, Kaisho, T, Kawai, T, Hemmi, H

J Exp Med 2004
17332413 Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

Garcia-Sastre, A, Chua, MA, Ng, SL, McWhirter, SM, Tenoever, BR, Maniatis, T

Science 2007
Participants
Events
Participates
as an event of
Inferred From
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
Authored
Shamovsky, V  (2009-08-27)
Reviewed
D'Eustachio, P  (2010-05-23)
Created
Shamovsky, V  (2009-08-27)
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