Reactome | palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:433591] serine C-palmitoyltransferase activity of SPTLC1:SPTLC2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:433625] D'Eustachio, P, 2009-08-22
dbId	433550
displayName	palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2
eventOf	[Pathway:R-GGA-433584] Sphingolipid metabolism - Gallus gallus
followingEvent	[Reaction:R-GGA-433576] 3-dehydrosphinganine + NADPH + H+ => sphinganine + NADP+ - Gallus gallus
inferredFrom	[Reaction:R-HSA-428127] SPTLC complexes transfer acyl-CoA onto serine - Homo sapiens
input	[SimpleEntity:R-ALL-200736] L-Ser [cytosol] [SimpleEntity:R-ALL-200993] PALM-CoA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2
output	[SimpleEntity:R-ALL-428182] 3-ketosphinganine [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-433550
summation	[Summation:433612] SPTLC (serine palmitoyltransferase) enzyme complexes associa...

(hasEvent)	[Pathway:R-GGA-433584] Sphingolipid metabolism
(precedingEvent)	[Reaction:R-GGA-433576] 3-dehydrosphinganine + NADPH + H+ => sphinganine + NADP+
(inferredTo)	[Reaction:R-HSA-428127] SPTLC complexes transfer acyl-CoA onto serine

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