palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2

Stable Identifier
R-GGA-433550
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol, endoplasmic reticulum membrane
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palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2
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SPTLC (serine palmitoyltransferase) enzyme complexes associated with the endoplasmic reticulum membrane catalyze the reaction of palmitoyl-CoA and serine to form 3-dehydrosphinganine. SPTLC2 and SPTLC3 polypeptides exhibit enzyme activity when either is complexed with SPTLC1. These chicken proteins are known only as the inferred products of genes predicted from the chicken genome sequence; their functional properties are inferred from those of their better-studied mammalian orthologues.

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Catalyst Activity

serine C-palmitoyltransferase activity of SPTLC 2 and 3 complexes [endoplasmic reticulum membrane]

Physical Entity
SPTLC 2 and 3 complexes [endoplasmic reticulum membrane] (Gallus gallus)
Activity
serine C-palmitoyltransferase activity (GO:0004758)
Inferred From
palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Homo sapiens)
Created
D'Eustachio, P  (2009-08-22)
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