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The phosphoribosylaminoimidazolecarboxamide formyltransferase activity of cytosolic ATIC (bifunctional purine biosynthesis protein PURH) catalyzes the reaction of 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) and 10-formyltetrahydrofolate to form 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) and tetrahydrofolate. The chicken protein has been purified and characterized biochemically (Muellerand Benkovic 1981); structural studies indicate that it occurs as a homodimer (Greasley et al. 2001).