5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate

Stable Identifier
R-GGA-419254
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
ReviewStatus
5/5
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5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
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The phosphoribosylaminoimidazolecarboxamide formyltransferase activity of cytosolic ATIC (bifunctional purine biosynthesis protein PURH) catalyzes the reaction of 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) and 10-formyltetrahydrofolate to form 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) and tetrahydrofolate. The chicken protein has been purified and characterized biochemically (Muellerand Benkovic 1981); structural studies indicate that it occurs as a homodimer (Greasley et al. 2001).
Literature References
PubMed ID Title Journal Year
7470484 On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver

Mueller, WT, Benkovic, SJ

Biochemistry 1981
11323713 Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis

Greasley, SE, Horton, P, Ramcharan, J, Beardsley, GP, Benkovic, SJ, Wilson, IA

Nat Struct Biol 2001
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Catalyst Activity

phosphoribosylaminoimidazolecarboxamide formyltransferase activity of ATIC dimer [cytosol]

Physical Entity
ATIC dimer [cytosol] (Gallus gallus)
Activity
phosphoribosylaminoimidazolecarboxamide formyltransferase activity (GO:0004643)
Authored
D'Eustachio, P  (2009-04-29)
Created
D'Eustachio, P  (2009-04-29)
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