Reactome | Degradation of cysteine and homocysteine

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Degradation of cysteine and homocysteine Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10827323
displayName	Degradation of cysteine and homocysteine
eventOf	[Pathway:R-GGA-1614635] Sulfur amino acid metabolism - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:10172] sulfur amino acid catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-1614631] Homocysteine is degraded to oxobutanoate and H2S - Gallus gallus [Reaction:R-GGA-1614614] Cysteine is degraded to pyruvate and H2S - Gallus gallus [Reaction:R-GGA-1614645] CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine - Gallus gallus [Reaction:R-GGA-6814153] ADO oxidises 2AET to HTAU - Gallus gallus [Reaction:R-GGA-6814165] PXLP-K333-GADL1 decarboxylates CSA to HTAU - Gallus gallus [Reaction:R-GGA-1655453] FMO1:FAD oxidizes HTAU to TAU - Gallus gallus [Reaction:R-GGA-1614567] Excess homocysteine yields homolanthionine and H2S - Gallus gallus [Reaction:R-GGA-1614591] Excess cysteine yields lanthionine and H2S - Gallus gallus [Reaction:R-GGA-9034756] MPST transfers sulfur atom from 3MPYR to form CysS248-MPST - Gallus gallus [Reaction:R-GGA-9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST - Gallus gallus [Reaction:R-GGA-9012721] MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR - Gallus gallus [Reaction:R-GGA-9013471] MPST transfers sulfur from 3MPYR to HCN to form HSCN - Gallus gallus [Reaction:R-GGA-9013533] MPST transfers sulfur from sulfanegen to HCN to form HSCN - Gallus gallus [Reaction:R-GGA-9013198] TST transfers sulfur from S2O3(2-) to HCN to form HSCN - Gallus gallus [Pathway:R-GGA-1614517] Sulfide oxidation to sulfate - Gallus gallus
inferredFrom	[Pathway:R-HSA-1614558] Degradation of cysteine and homocysteine - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Degradation of cysteine and homocysteine
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-1614558
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1614635] Sulfur amino acid metabolism
(inferredTo)	[Pathway:R-HSA-1614558] Degradation of cysteine and homocysteine

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