Reactome | Collagen degradation

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Collagen degradation Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10827251
displayName	Collagen degradation
eventOf	[Pathway:R-GGA-1474228] Degradation of the extracellular matrix - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23851] collagen catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-GGA-1474213] Collagen type III degradation by MMP1,8,9,13 - Gallus gallus [Reaction:R-GGA-1474210] Collagen type III degradation by MMP14 - Gallus gallus [BlackBoxEvent:R-GGA-2473584] Collagen type III degradation by MMP15 - Gallus gallus [Reaction:R-GGA-1564142] Collagen type IV degradation by MMP2,3,4,9,10,12 - Gallus gallus [Reaction:R-GGA-2168046] Collagen type XII degradation by MMP12 - Gallus gallus [Reaction:R-GGA-2168923] Collagen type XVIII endostatin release - Gallus gallus [BlackBoxEvent:R-GGA-2471621] Endostatin degradation by cathepsins - Gallus gallus [BlackBoxEvent:R-GGA-2172433] Collagen type XIX degradation - Gallus gallus [BlackBoxEvent:R-GGA-2167942] Collagen type XIII ectodomain shedding - Gallus gallus [Reaction:R-GGA-2471842] Collagen type XXV ectomain shedding - Gallus gallus [BlackBoxEvent:R-GGA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Gallus gallus [Reaction:R-GGA-5696408] PXLP-K278-PHYKPL tetramer hydrolyses 5PHL - Gallus gallus
inferredFrom	[Pathway:R-HSA-1442490] Collagen degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Collagen degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-1442490
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1474228] Degradation of the extracellular matrix
(inferredTo)	[Pathway:R-HSA-1442490] Collagen degradation

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