Reactome | Collagen type III degradation by MMP14

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Collagen type III degradation by MMP14 Show undefined attributes

catalystActivity	[CatalystActivity:10771987] metalloendopeptidase activity of MMP14,TMPRSS6 [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10771989
displayName	Collagen type III degradation by MMP14
eventOf	[Pathway:R-GGA-1442490] Collagen degradation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-GGA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Gallus gallus
inferredFrom	[Reaction:R-HSA-1474210] Collagen type III degradation by MMP14 - Homo sapiens
input	[Polymer:R-GGA-1474212] Collagen type III fibril [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Collagen type III degradation by MMP14
output	[Polymer:R-GGA-2468104] Cleaved collagen type III fibril [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1474210
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1442490] Collagen degradation
(precedingEvent)	[BlackBoxEvent:R-GGA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
(inferredTo)	[Reaction:R-HSA-1474210] Collagen type III degradation by MMP14

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