Another MAP3K, MEKK1, has been reported to induce IKK and MAPK activation in RIG1 signaling pathway in response to dsRNA.[Yoshida R et al 2008]. TNF receptor associated factor (TRAF) protein family members are E3 ligases that have been implicated in various signal transduction pathways including RLR signaling and Toll-like receptors (TLRs) leading to activation of NFkB, MAPK and IRF family members [Oganesyan G et al 2006, Xia et al 2009, Sasai M et al 2010].
Xu, LG, Shu, HB, Han, KJ, Wang, YY, Zhai, Z, Li, LY
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