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CBL [cytosol]
Stable Identifier
R-GGA-112199
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
CBL, F1NXW5
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-6 family signaling (Gallus gallus)
Interleukin-6 signaling (Gallus gallus)
PTPN11 binds CBL (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by EGFR (Gallus gallus)
EGFR downregulation (Gallus gallus)
CBL binds to GRB2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Gallus gallus)
CBL [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL ubiquitinates Sprouty (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL-mediated ubiquitination of CIN85 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CDC42:GTP binds CBL:Beta-Pix (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Sprouty lures CBL away from EGFR (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL:SPRY1/2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by FGFR (Gallus gallus)
Signaling by FGFR1 (Gallus gallus)
Negative regulation of FGFR1 signaling (Gallus gallus)
Spry regulation of FGF signaling (Gallus gallus)
CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by FGFR2 (Gallus gallus)
Negative regulation of FGFR2 signaling (Gallus gallus)
Spry regulation of FGF signaling (Gallus gallus)
CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by FGFR3 (Gallus gallus)
Negative regulation of FGFR3 signaling (Gallus gallus)
Spry regulation of FGF signaling (Gallus gallus)
CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by FGFR4 (Gallus gallus)
Negative regulation of FGFR4 signaling (Gallus gallus)
Spry regulation of FGF signaling (Gallus gallus)
CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by MET (Gallus gallus)
Negative regulation of MET activity (Gallus gallus)
CBL binds MET (Gallus gallus)
CBL:GRB2,CBL [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
MET phosphorylates CBL (Gallus gallus)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by SCF-KIT (Gallus gallus)
Regulation of KIT signaling (Gallus gallus)
Recruitment of CBL to KIT (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by TGFB family members (Gallus gallus)
Signaling by TGF-beta Receptor Complex (Gallus gallus)
TGF-beta receptor signaling activates SMADs (Gallus gallus)
CBL binds TGFBR2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
TGFBR2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL neddylates TGFBR2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
TGFBR2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1NXW5
Gene Names
CBL
Reference Genes
ENSEMBL:ENSGALG00000029077
Other Identifiers
374038
GO:0001784
GO:0003674
GO:0004842
GO:0005509
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0005929
GO:0006464
GO:0006511
GO:0006810
GO:0007165
GO:0007166
GO:0008150
GO:0008219
GO:0009056
GO:0014068
GO:0016192
GO:0016567
GO:0016600
GO:0017124
GO:0023051
GO:0032487
GO:0032991
GO:0042059
GO:0043066
GO:0043167
GO:0043226
GO:0046875
GO:0048260
GO:2000583
GT_A_87_P037692
Gga.194.1.S1_at
Participates
as an input of
CBL binds TGFBR2 (Gallus gallus)
CBL binds to GRB2 (Gallus gallus)
CDC42:GTP binds CBL:Beta-Pix (Gallus gallus)
PTPN11 binds CBL (Gallus gallus)
Recruitment of CBL to KIT (Gallus gallus)
Sprouty lures CBL away from EGFR (Gallus gallus)
as a component of
CBL:Beta-Pix:CDC42:GTP [cytosol] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Gallus gallus)
CBL:SPRY1/2 [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Gallus gallus)
TGFBR2:CBL [plasma membrane] (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
as an output of
CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)
CBL neddylates TGFBR2 (Gallus gallus)
as a candidate of
CBL:GRB2,CBL [cytosol] (Gallus gallus)
Other forms of this molecule
phospho-CBL [cytosol]
phospho-CBL [plasma membrane]
phospho-CBL [cytosol]
phospho-CBL [cytosol]
phospho-CBL [cytosol]
Inferred From
CBL [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000110395
Ensembl
ENSGALP00000010935
,
ENSGALG00000029077
,
ENSGALT00000010949
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