Reactome | TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-DRE-9824875] CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] - Danio rerio
consumedByEvent	[Reaction:R-DRE-9824874] OPTN recruits CYLD to the TNFR1 complex - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10642942
displayName	TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane]
hasComponent	[GenomeEncodedEntity:R-DRE-9793686] Ghost homologue of TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] [EntityWithAccessionedSequence:R-DRE-9687907] OPTN [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-9793672] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] - Homo sapiens
maxDepth	2
name	TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-9793672
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DRE-9824874] OPTN recruits CYLD to the TNFR1 complex
(hasComponent)	[Complex:R-DRE-9824875] CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane]
(inferredTo)	[Complex:R-HSA-9793672] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane]

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