Reactome | Neddylation

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Neddylation Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10650110
displayName	Neddylation
eventOf	[Pathway:R-DRE-597592] Post-translational protein modification - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DRE-5690808] UCHL3, SENP8 cleave NEDD8 - Danio rerio [Reaction:R-DRE-8951644] Release of mature NEDD8 - Danio rerio [Reaction:R-DRE-8955241] CAND1 binds cytosolic CRL E3 ubiquitin ligases - Danio rerio [Reaction:R-DRE-8955289] COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes - Danio rerio [Reaction:R-DRE-8956200] MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8955245] CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus - Danio rerio [Reaction:R-DRE-8955285] COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8952620] NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8952618] AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8952625] NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8952626] AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8952630] NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8952631] AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8952639] NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8952039] NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8952044] AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Danio rerio [Reaction:R-DRE-8956045] COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-8956103] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha - Danio rerio [Reaction:R-DRE-8956106] VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha - Danio rerio [BlackBoxEvent:R-DRE-9755303] 26S proteasome degrades HIFalpha - Danio rerio [Reaction:R-DRE-8956099] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 - Danio rerio [Reaction:R-DRE-9755304] MUL1 ubiquitinates UBXN7 - Danio rerio [BlackBoxEvent:R-DRE-9755306] ub UBXN7 is degraded by the 26S proteasome - Danio rerio [Reaction:R-DRE-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Danio rerio [Reaction:R-DRE-9758088] UBXN7 binds VCP hexamer:UBF1:NPLOC4 - Danio rerio [Reaction:R-DRE-9755507] UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex - Danio rerio [Reaction:R-DRE-9758090] Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation - Danio rerio [BlackBoxEvent:R-DRE-8932355] 26S proteasome degrades Ub-NFE2L2 - Danio rerio
inferredFrom	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Neddylation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-8951664
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-597592] Post-translational protein modification
(inferredTo)	[Pathway:R-HSA-8951664] Neddylation

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