Reactome | PTK6 phosphorylates CDKN1B

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PTK6 phosphorylates CDKN1B Show undefined attributes

catalystActivity	[CatalystActivity:10629264] protein tyrosine kinase activity of p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10629266
displayName	PTK6 phosphorylates CDKN1B
eventOf	[Pathway:R-DRE-8849470] PTK6 Regulates Cell Cycle - Danio rerio [Pathway:R-DRE-187577] SCF(Skp2)-mediated degradation of p27/p21 - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DRE-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Danio rerio
inferredFrom	[Reaction:R-HSA-8848436] PTK6 phosphorylates CDKN1B - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DRE-8848415] p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PTK6 phosphorylates CDKN1B BRK phosphorylates p27KIP1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DRE-8848441] p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] [EntityWithAccessionedSequence:R-DRE-8848007] phospho-p-Y342-PTK6 [cytosol]
precedingEvent	[Reaction:R-DRE-8848414] Activated PTK6 binds CDKN1B - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-8848436
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-8849470] PTK6 Regulates Cell Cycle [Pathway:R-DRE-187577] SCF(Skp2)-mediated degradation of p27/p21
(precedingEvent)	[BlackBoxEvent:R-DRE-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus
(inferredTo)	[Reaction:R-HSA-8848436] PTK6 phosphorylates CDKN1B