Reactome | phospho-p-Y342-PTK6 [cytosol]

candidateOf	[CandidateSet:R-DRE-8942611] (p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2) [cytosol] - Danio rerio
catalystActivities	[CatalystActivity:10629457] protein tyrosine kinase activity of p-Y342-PTK6 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DRE-8848073] p-Y342-PTK6:p-Y250-STAP2 [cytosol] - Danio rerio [Complex:R-DRE-8848108] p-Y342-PTK6:SOCS3 [cytosol] - Danio rerio
consumedByEvent	[Reaction:R-DRE-8849102] SRMS phosphorylates PTK6 - Danio rerio [Reaction:R-DRE-8848023] Activated PTK6 binds STAP2 - Danio rerio [Reaction:R-DRE-8848751] PTK6 binds AKT1 - Danio rerio [Reaction:R-DRE-8848864] PTK6 binds ARAP1 - Danio rerio [Reaction:R-DRE-8848774] PTK6 binds DOK1 - Danio rerio [Reaction:R-DRE-8848930] PTK6 translocates to the nucleus - Danio rerio [Reaction:R-DRE-8849055] PTK6 binds ARHGAP35 - Danio rerio [Reaction:R-DRE-8848414] Activated PTK6 binds CDKN1B - Danio rerio [Reaction:R-DRE-8848110] SOCS3 binds activated PTK6 - Danio rerio [Reaction:R-DRE-8848596] PTK6 binds PXN - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10629151
displayName	phospho-p-Y342-PTK6 [cytosol]
endCoordinate	451
hasModifiedResidue	[ModifiedResidue:10629149] O4'-phospho-L-tyrosine at 342 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-8848007] p-Y342-PTK6 [cytosol] - Homo sapiens
maxDepth	1
name	phospho-p-Y342-PTK6 Q08BY6
producedByEvent	[Reaction:R-DRE-8848873] PTK6 phosphorylates ARAP1 - Danio rerio [Reaction:R-DRE-8848776] PTK6 phosphorylates DOK1 - Danio rerio [Reaction:R-DRE-8848606] PTK6 phosphorylates PXN - Danio rerio [Reaction:R-DRE-8848005] ERBB2 promotes PTK6 autophosphorylation - Danio rerio [Reaction:R-DRE-8849068] PTK6 phosphorylates ARHGAP35 - Danio rerio [Reaction:R-DRE-8848436] PTK6 phosphorylates CDKN1B - Danio rerio
referenceEntity	[ReferenceGeneProduct:uniprot:Q08BY6] UniProt:Q08BY6
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:68323] Danio rerio
stId	R-DRE-8848007
startCoordinate	1

(input)	[Reaction:R-DRE-8849102] SRMS phosphorylates PTK6 [Reaction:R-DRE-8848110] SOCS3 binds activated PTK6 [Reaction:R-DRE-8848023] Activated PTK6 binds STAP2 [Reaction:R-DRE-8848751] PTK6 binds AKT1 [Reaction:R-DRE-8848864] PTK6 binds ARAP1 [Reaction:R-DRE-8848774] PTK6 binds DOK1 [Reaction:R-DRE-8848930] PTK6 translocates to the nucleus [Reaction:R-DRE-8849055] PTK6 binds ARHGAP35 [Reaction:R-DRE-8848596] PTK6 binds PXN [Reaction:R-DRE-8848414] Activated PTK6 binds CDKN1B
(hasComponent)	[Complex:R-DRE-8848108] p-Y342-PTK6:SOCS3 [cytosol] [Complex:R-DRE-8848073] p-Y342-PTK6:p-Y250-STAP2 [cytosol] [Complex:R-DRE-8848029] p-Y342-PTK6:STAP2 [cytosol] [Complex:R-DRE-8848769] p-Y342-PTK6:p-Y315,Y326-AKT1 [cytosol] [Complex:R-DRE-8848750] p-Y342-PTK6:AKT1 [cytosol] [Complex:R-DRE-8848862] p-Y342-PTK6:ARAP1 [cytosol] [Complex:R-DRE-8848773] p-Y342-PTK6:DOK1 [cytosol] [Complex:R-DRE-8849058] p-Y342-PTK6:ARHGAP35 [cytosol] [Complex:R-DRE-8848597] p-Y342-PTK6:PXN [cytosol] [Complex:R-DRE-8848415] p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol]
(activeUnit)	[CatalystActivity:10629173] protein tyrosine kinase activity of p-Y342-PTK6:STAP2 [cytosol] [CatalystActivity:10629477] protein tyrosine kinase activity of p-Y342-PTK6:ARAP1 [cytosol] [CatalystActivity:10629438] protein tyrosine kinase activity of p-Y342-PTK6:AKT1 [cytosol] [CatalystActivity:10629452] protein tyrosine kinase activity of p-Y342-PTK6:DOK1 [cytosol] [CatalystActivity:10629521] protein tyrosine kinase activity of p-Y342-PTK6:ARHGAP35 [cytosol] [CatalystActivity:10629298] protein tyrosine kinase activity of p-Y342-PTK6:PXN [cytosol] [CatalystActivity:10629264] protein tyrosine kinase activity of p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol]
(output)	[Reaction:R-DRE-8848873] PTK6 phosphorylates ARAP1 [Reaction:R-DRE-8848776] PTK6 phosphorylates DOK1 [Reaction:R-DRE-8849068] PTK6 phosphorylates ARHGAP35 [Reaction:R-DRE-8848606] PTK6 phosphorylates PXN [Reaction:R-DRE-8848436] PTK6 phosphorylates CDKN1B [Reaction:R-DRE-8848005] ERBB2 promotes PTK6 autophosphorylation
(physicalEntity)	[CatalystActivity:10629457] protein tyrosine kinase activity of p-Y342-PTK6 [cytosol]
(hasCandidate)	[CandidateSet:R-DRE-8942611] (p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2) [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-8848007] p-Y342-PTK6 [cytosol]

phospho-p-Y342-PTK6 [cytosol] Show undefined attributes

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