Reactome | AKT phosphorylates FOXO transcription factors

Schema > Reaction > Entries

AKT phosphorylates FOXO transcription factors Show undefined attributes

catalystActivity	[CatalystActivity:10575143] protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10575186
displayName	AKT phosphorylates FOXO transcription factors
eventOf	[Pathway:R-DRE-9614399] Regulation of localization of FOXO transcription factors - Danio rerio [Pathway:R-DRE-198693] AKT phosphorylates targets in the nucleus - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DRE-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Danio rerio
goBiologicalProcess	[GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferredFrom	[Reaction:R-HSA-199299] AKT phosphorylates FOXO transcription factors - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [CandidateSet:R-DRE-199272] FOXO1,FOXO3,FOXO4,(FOXO6) [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	AKT phosphorylates FOXO transcription factors
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [CandidateSet:R-DRE-9614997] p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6) [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-199299
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9614399] Regulation of localization of FOXO transcription factors [Pathway:R-DRE-198693] AKT phosphorylates targets in the nucleus
(precedingEvent)	[BlackBoxEvent:R-DRE-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol
(inferredTo)	[Reaction:R-HSA-199299] AKT phosphorylates FOXO transcription factors