Reactome | WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10575909] protein serine/threonine kinase activity of WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-DRE-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10575895
displayName	WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane]
hasComponent	[Complex:R-DRE-1504204] GSK3B:AXIN1 [cytosol] [Complex:R-DRE-1504192] WNT:FZD:LRP5/6:DVL [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-1504184] WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] - Homo sapiens
maxDepth	5
name	WNT:FZD:LRP5/6:DVL:AXIN:GSK3B
producedByEvent	[Reaction:R-DRE-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-1504184
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DRE-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta
(physicalEntity)	[CatalystActivity:10575909] protein serine/threonine kinase activity of WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane]
(output)	[Reaction:R-DRE-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex
(inferredTo)	[Complex:R-HSA-1504184] WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane]

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