Reactome | Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-DRE-1112759] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] - Danio rerio [Complex:R-DRE-9958926] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT3 [plasma membrane] - Danio rerio
consumedByEvent	[Reaction:R-DRE-1112755] SOCS3 binds IL6ST - Danio rerio [Reaction:R-DRE-1112565] Tyrosine phosphorylated IL6ST binds STAT1,STAT3 - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10566316
displayName	Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]
hasComponent	2 × [DefinedSet:R-DRE-1112584] IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] - Homo sapiens
maxDepth	6
name	Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs
producedByEvent	[Reaction:R-DRE-1112604] Phosphorylated STATs are released - Danio rerio [BlackBoxEvent:R-DRE-1112510] IL6ST is tyrosine phosphorylated - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-1112594
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DRE-1112755] SOCS3 binds IL6ST [Reaction:R-DRE-1112565] Tyrosine phosphorylated IL6ST binds STAT1,STAT3
(hasComponent)	[Complex:R-DRE-1112759] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] [Complex:R-DRE-1112718] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] [Complex:R-DRE-1112524] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] [Complex:R-DRE-1112576] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] [Complex:R-DRE-1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] [Complex:R-DRE-9958926] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT3 [plasma membrane] [Complex:R-DRE-9958930] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:p-Y705-STAT3 [plasma membrane] [Complex:R-DRE-1112753] IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane]
(output)	[Reaction:R-DRE-1112604] Phosphorylated STATs are released [BlackBoxEvent:R-DRE-1112510] IL6ST is tyrosine phosphorylated
(inferredTo)	[Complex:R-HSA-1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]

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