Reactome | 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi

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5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi Show undefined attributes

catalystActivity	[CatalystActivity:10833273] phosphoribosylamine-glycine ligase activity of GART [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10833275
displayName	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi
eventOf	[Pathway:R-DME-73817] Purine ribonucleoside monophosphate biosynthesis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-73813] GAR + 10-Formyl-THF => FGAR + THF - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-73814] 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29424] Gly [cytosol] [SimpleEntity:R-ALL-111292] PRA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi 5-phospho-beta-D-ribosylamine + glycine + ATP => N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+) 5-phosphoribosylamine + glycine + ATP => 5-phosphoribosylglycinamide (GAR) + ADP + orthophosphate
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-111338] PRGA [cytosol]
precedingEvent	[Reaction:R-DME-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-73814
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-73817] Purine ribonucleoside monophosphate biosynthesis
(precedingEvent)	[Reaction:R-DME-73813] GAR + 10-Formyl-THF => FGAR + THF
(inferredTo)	[Reaction:R-HSA-73814] 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi

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