Reactome | IMPDH tetramers bind IMPDH inhibitors

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10904246
displayName	IMPDH tetramers bind IMPDH inhibitors
eventOf	[Pathway:R-DME-73817] Purine ribonucleoside monophosphate biosynthesis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9678749] IMPDH tetramers bind IMPDH inhibitors - Homo sapiens
input	[DefinedSet:R-ALL-9678719] IMPDH inhibitors [cytosol] [Complex:R-DME-111583] IMPDH1 tetramer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IMPDH tetramers bind IMPDH inhibitors
output	[Complex:R-DME-9679104] IMPDH tetramers:IMPDH inhibitors [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9678749
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-73817] Purine ribonucleoside monophosphate biosynthesis
(inferredTo)	[Reaction:R-HSA-9678749] IMPDH tetramers bind IMPDH inhibitors

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