Reactome | Homologues of RB1 [nucleoplasm]

Schema > DefinedSet > Entries

Homologues of RB1 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-DME-113646] RB1:RNA primer-DNA primer:origin duplex with DNA damage [nucleoplasm] - Drosophila melanogaster [Complex:R-DME-188192] PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] - Drosophila melanogaster [Complex:R-DME-9686978] RB1:SKP2:APC/C:Cdh1 [nucleoplasm] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes - Drosophila melanogaster [Reaction:R-DME-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 - Drosophila melanogaster [Reaction:R-DME-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10830210
displayName	Homologues of RB1 [nucleoplasm]
hasMember	[EntityWithAccessionedSequence:R-DME-68642] Rbf [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-68642-2] Rbf2 [nucleoplasm] - Drosophila melanogaster
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-68642] RB1 [nucleoplasm] - Homo sapiens
maxDepth	2
name	Homologues of RB1
positivelyRegulates	[PositiveRegulation:10907774] Positive regulation by 'RB1 [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-DME-9659820] RB1 translocates to the nucleus - Drosophila melanogaster [BlackBoxEvent:R-DME-188191] APC/C:Cdh1-mediated degradation of Skp2 - Drosophila melanogaster
schemaClass	DefinedSet
species	[Species:56210] Drosophila melanogaster
stId	R-DME-68642-3

Referrals

(regulator)	[PositiveRegulation:10907774] Positive regulation by 'RB1 [nucleoplasm]'
(hasComponent)	[Complex:R-DME-113646] RB1:RNA primer-DNA primer:origin duplex with DNA damage [nucleoplasm] [Complex:R-DME-68644] RB1:E2F1,E2F2,E2F3:TFDP1,TFDP2: [nucleoplasm] [Complex:R-DME-9686978] RB1:SKP2:APC/C:Cdh1 [nucleoplasm] [Complex:R-DME-188192] PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm]
(input)	[Reaction:R-DME-9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes [Reaction:R-DME-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 [Reaction:R-DME-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
(output)	[BlackBoxEvent:R-DME-188191] APC/C:Cdh1-mediated degradation of Skp2 [BlackBoxEvent:R-DME-9659820] RB1 translocates to the nucleus
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-68642] RB1 [nucleoplasm]

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