Reactome | RB1:SKP2:APC/C:Cdh1 [nucleoplasm]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10904373] ubiquitin protein ligase activity of RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-DME-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10904372
displayName	RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
hasComponent	[Complex:R-DME-174250] Cdh1:phospho-APC/C complex [nucleoplasm] [DefinedSet:R-DME-68642-3] Homologues of RB1 [nucleoplasm] [EntityWithAccessionedSequence:R-DME-975554] Skp2 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-9686978] RB1:SKP2:APC/C:Cdh1 [nucleoplasm] - Homo sapiens
maxDepth	4
name	RB1:SKP2:APC/C:Cdh1
producedByEvent	[Reaction:R-DME-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 - Drosophila melanogaster
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9686978
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DME-9686969] APC/C:Cdh1 polyubiquitinates SKP2
(physicalEntity)	[CatalystActivity:10904373] ubiquitin protein ligase activity of RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
(output)	[Reaction:R-DME-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2
(inferredTo)	[Complex:R-HSA-9686978] RB1:SKP2:APC/C:Cdh1 [nucleoplasm]

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