Reactome | RB1 binds and inhibits E2F1/2/3:DP1/2 complexes

Schema > Reaction > Entries

RB1 binds and inhibits E2F1/2/3:DP1/2 complexes Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10901814
displayName	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes
eventOf	[Pathway:R-DME-69231] Cyclin D associated events in G1 - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes - Homo sapiens
input	[Complex:R-DME-1227905] E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] [DefinedSet:R-DME-68642-3] Homologues of RB1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes
output	[Complex:R-DME-68644] RB1:E2F1,E2F2,E2F3:TFDP1,TFDP2: [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-DME-9659820] RB1 translocates to the nucleus - Drosophila melanogaster
regulatedBy	[NegativeRegulation:10901815] Negative regulation by 'p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]' [NegativeRegulation:10901816] Negative regulation by 'Cyclin E:p-T160-CDK2 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9018017
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-69231] Cyclin D associated events in G1
(inferredTo)	[Reaction:R-HSA-9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes

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