Reactome | Stabilization of p53

Schema > Pathway > Entries

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10910602
displayName	Stabilization of p53
eventOf	[Pathway:R-DME-69563] p53-Dependent G1 DNA Damage Response - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-5693609] ATM phosphorylates TP53 at S15 - Drosophila melanogaster [Reaction:R-DME-69685] CHEK2 phosphorylates TP53 - Drosophila melanogaster [Reaction:R-DME-6793685] Ubiquitinated TP53 translocates to the cytosol - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-69541] Stabilization of p53 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Stabilization of p53
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-69541
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-69563] p53-Dependent G1 DNA Damage Response
(inferredTo)	[Pathway:R-HSA-69541] Stabilization of p53