Reactome | RAF/MAP kinase cascade

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RAF/MAP kinase cascade Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912862
displayName	RAF/MAP kinase cascade
eventOf	[Pathway:R-DME-5684996] MAPK1/MAPK3 signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21714] MAPK cascade
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DME-9648002] RAS processing - Drosophila melanogaster [Reaction:R-DME-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP - Drosophila melanogaster [Reaction:R-DME-9649735] Intrinsic nucleotide exchange on RAS - Drosophila melanogaster [Reaction:R-DME-5672965] RAS GEFs promote RAS nucleotide exchange - Drosophila melanogaster [Reaction:R-DME-9658253] RAS:GTP binds PI3K - Drosophila melanogaster [Reaction:R-DME-9660557] RAS:GTP binds RAL GDS proteins - Drosophila melanogaster [Pathway:R-DME-5673000] RAF activation - Drosophila melanogaster [Pathway:R-DME-5674135] MAP2K and MAPK activation - Drosophila melanogaster [Reaction:R-DME-5674385] p-T,Y MAPKs dimerize - Drosophila melanogaster [BlackBoxEvent:R-DME-5674387] Phosphorylated MAPKs translocate into the nucleus - Drosophila melanogaster [Pathway:R-DME-5675221] Negative regulation of MAPK pathway - Drosophila melanogaster [Pathway:R-DME-5658442] Regulation of RAS by GAPs - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	RAF/MAP kinase cascade
precedingEvent	[Reaction:R-DME-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5673001
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(inferredTo)	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
(hasEvent)	[Pathway:R-DME-5684996] MAPK1/MAPK3 signaling
(hasEncapsulatedEvent)	[Pathway:R-DME-201556] Signaling by ALK [Pathway:R-DME-9607240] FLT3 Signaling [Pathway:R-DME-8853659] RET signaling [Pathway:R-DME-1257604] PIP3 activates AKT signaling [Pathway:R-DME-881907] Gastrin-CREB signalling pathway via PKC and MAPK [Pathway:R-DME-1236394] Signaling by ERBB4 [Pathway:R-DME-8878166] Transcriptional regulation by RUNX2 [Pathway:R-DME-1433557] Signaling by SCF-KIT [Pathway:R-DME-9648002] RAS processing [Pathway:R-DME-5654743] Signaling by FGFR4 [Pathway:R-DME-74752] Signaling by Insulin receptor [Pathway:R-DME-442755] Activation of NMDA receptors and postsynaptic events [Pathway:R-DME-187037] Signaling by NTRK1 (TRKA) [Pathway:R-DME-2404192] Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) [Pathway:R-DME-2454202] Fc epsilon receptor (FCERI) signaling [Pathway:R-DME-2172127] DAP12 interactions [Pathway:R-DME-1227986] Signaling by ERBB2 [Pathway:R-DME-177929] Signaling by EGFR [Pathway:R-DME-8848021] Signaling by PTK6 [Pathway:R-DME-194138] Signaling by VEGF [Pathway:R-DME-9009391] Extra-nuclear estrogen signaling [Pathway:R-DME-451927] Interleukin-2 family signaling [Pathway:R-DME-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling [Pathway:R-DME-5654736] Signaling by FGFR1 [Pathway:R-DME-5654741] Signaling by FGFR3 [Pathway:R-DME-186797] Signaling by PDGF [Pathway:R-DME-375165] NCAM signaling for neurite out-growth [Pathway:R-DME-5654738] Signaling by FGFR2

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