Reactome | Rheb in the MTORC1 complex hydrolyses GTP

Schema > Reaction > Entries

Rheb in the MTORC1 complex hydrolyses GTP Show undefined attributes

catalystActivity	[CatalystActivity:10881108] GTPase activity of MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10881112
displayName	Rheb in the MTORC1 complex hydrolyses GTP
eventOf	[Pathway:R-DME-1632852] Macroautophagy - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24370] regulation of macroautophagy
inferredFrom	[Reaction:R-HSA-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Homo sapiens
input	[Complex:R-DME-165678] Active mTORC1 complex [lysosomal membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Rheb in the MTORC1 complex hydrolyses GTP
output	[Complex:R-DME-5693447] mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane]
precedingEvent	[Reaction:R-DME-165680] Formation of active mTORC1 complex - Drosophila melanogaster [Reaction:R-DME-380927] p-AMPK phosphorylates TSC1:TSC2 - Drosophila melanogaster
regulatedBy	[PositiveRegulation:10881113] Positive regulation by 'TSC1:p-S1387-TSC2 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5672017
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1632852] Macroautophagy
(inferredTo)	[Reaction:R-HSA-5672017] Rheb in the MTORC1 complex hydrolyses GTP

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