Reactome | Active mTORC1 complex [lysosomal membrane]

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Active mTORC1 complex [lysosomal membrane] Show undefined attributes

catalystActivities	[CatalystActivity:10839290] protein serine/threonine kinase activity of Active mTORC1 complex [lysosomal membrane] [CatalystActivity:10899061] protein serine/threonine kinase activity of MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] [CatalystActivity:10881108] GTPase activity of MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] [CatalystActivity:10848827] GTPase activity of Active mTORC1 complex [lysosomal membrane]
compartment	[Compartment:17938] lysosomal membrane
componentOf	[Complex:R-DME-5672831] mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] - Drosophila melanogaster [Complex:R-DME-5675639] MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-447074] AMPK phosphorylates Raptor in the mTORC1 complex - Drosophila melanogaster [Reaction:R-DME-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Drosophila melanogaster [Reaction:R-DME-380979] RHEB in mTORC1:RHEB:GTP hydrolyses GTP - Drosophila melanogaster [Reaction:R-DME-5672817] Active MTORC1 binds the ULK1 complex - Drosophila melanogaster [Reaction:R-DME-5672843] AKT1S1 (PRAS40) binds mTORC1 - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10839281
displayName	Active mTORC1 complex [lysosomal membrane]
hasComponent	[Complex:R-DME-5653972] mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] [Complex:R-DME-165189] RHEB:GTP [lysosomal membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-165678] Active mTORC1 complex [lysosomal membrane] - Homo sapiens [Complex:R-HSA-5672812] MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] - Homo sapiens
maxDepth	8
name	Active mTORC1 complex
negativelyRegulates	[NegativeRegulation:10899066] Negative regulation by 'mTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]'
producedByEvent	[Reaction:R-DME-165680] Formation of active mTORC1 complex - Drosophila melanogaster [Reaction:R-DME-377186] Activated AKT phosphorylates AKT1S1 (PRAS40) - Drosophila melanogaster
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-165678
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(physicalEntity)	[CatalystActivity:10839290] protein serine/threonine kinase activity of Active mTORC1 complex [lysosomal membrane] [CatalystActivity:10899061] protein serine/threonine kinase activity of MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] [CatalystActivity:10881108] GTPase activity of MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] [CatalystActivity:10848827] GTPase activity of Active mTORC1 complex [lysosomal membrane]
(output)	[Reaction:R-DME-377186] Activated AKT phosphorylates AKT1S1 (PRAS40) [Reaction:R-DME-165680] Formation of active mTORC1 complex
(input)	[Reaction:R-DME-5672843] AKT1S1 (PRAS40) binds mTORC1 [Reaction:R-DME-447074] AMPK phosphorylates Raptor in the mTORC1 complex [Reaction:R-DME-5672017] Rheb in the MTORC1 complex hydrolyses GTP [Reaction:R-DME-380979] RHEB in mTORC1:RHEB:GTP hydrolyses GTP [Reaction:R-DME-5672817] Active MTORC1 binds the ULK1 complex
(hasComponent)	[Complex:R-DME-5672831] mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] [Complex:R-DME-5675639] MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] [Complex:R-DME-5675701] MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane]
(regulator)	[NegativeRegulation:10899066] Negative regulation by 'mTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]'
(inferredTo)	[Complex:R-HSA-165678] Active mTORC1 complex [lysosomal membrane] [Complex:R-HSA-5672812] MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]

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