Reactome | p-AMPK phosphorylates TSC1:TSC2

Schema > Reaction > Entries

p-AMPK phosphorylates TSC1:TSC2 Show undefined attributes

catalystActivity	[CatalystActivity:10848810] AMP-activated protein kinase activity of p-AMPK heterotrimer:AMP [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10848812
displayName	p-AMPK phosphorylates TSC1:TSC2
eventOf	[Pathway:R-DME-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Drosophila melanogaster [Pathway:R-DME-5628897] TP53 Regulates Metabolic Genes - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-380927] p-AMPK phosphorylates TSC1:TSC2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DME-165175] TSC1:TSC2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p-AMPK phosphorylates TSC1:TSC2
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DME-381855] TSC1:p-S1387-TSC2 [plasma membrane]
precedingEvent	[Reaction:R-DME-380930] Phosphorylated AMPK binds AMP - Drosophila melanogaster [Reaction:R-DME-165179] Formation of TSC1:TSC2 complex - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-380927
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5628897] TP53 Regulates Metabolic Genes [Pathway:R-DME-380972] Energy dependent regulation of mTOR by LKB1-AMPK
(precedingEvent)	[Reaction:R-DME-5672017] Rheb in the MTORC1 complex hydrolyses GTP
(inferredTo)	[Reaction:R-HSA-380927] p-AMPK phosphorylates TSC1:TSC2