Reactome | Rheb in the MTORC1 complex hydrolyses GTP

Schema > Reaction > Entries

Rheb in the MTORC1 complex hydrolyses GTP Show undefined attributes

authored	[InstanceEdit:5671581] Jupe, Steve, 2015-02-02
catalystActivity	[CatalystActivity:5672134] GTPase activity of MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:5672023] Jupe, Steve, 2015-02-04
dbId	5672017
displayName	Rheb in the MTORC1 complex hydrolyses GTP
edited	[InstanceEdit:5692984] Jupe, Steve, 2015-05-13
eventOf	[Pathway:R-HSA-1632852] Macroautophagy - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24370] regulation of macroautophagy
input	[Complex:R-HSA-5672812] MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:447068] AMPK phosphorylation of raptor mediates a metabolic checkpoint
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Rheb in the MTORC1 complex hydrolyses GTP
orthologousEvent	[Reaction:R-DDI-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Dictyostelium discoideum [Reaction:R-CEL-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Caenorhabditis elegans [Reaction:R-DME-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Drosophila melanogaster [Reaction:R-GGA-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Gallus gallus [Reaction:R-XTR-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Xenopus tropicalis [Reaction:R-DRE-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Danio rerio [Reaction:R-SSC-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Sus scrofa [Reaction:R-BTA-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Bos taurus [Reaction:R-CFA-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Canis familiaris [Reaction:R-RNO-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Rattus norvegicus [Reaction:R-MMU-5672017] Rheb in the MTORC1 complex hydrolyses GTP - Mus musculus
output	[Complex:R-HSA-5672139] MTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane]
precedingEvent	[Reaction:R-HSA-165680] Formation of active mTORC1 complex - Homo sapiens [Reaction:R-HSA-380927] p-AMPK phosphorylates TSC1:TSC2 - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-5672336] Positive regulation by 'TSC1:p-S1387-TSC2 [cytosol]'
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693008] Tooze, Sharon A, 2015-05-13 [InstanceEdit:6793656] Klionsky, Daniel J, 2015-09-03
revised	[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5672017
summation	[Summation:5672128] When cellular energy is depleted AMPK is activated and inhib...

Referrals

(hasEvent)

[Pathway:R-HSA-1632852] Macroautophagy