Reactome | Complex IV assembly

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Complex IV assembly Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10913432
displayName	Complex IV assembly
eventOf	[Pathway:R-DME-611105] Respiratory electron transport - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:261940] mitochondrial respiratory chain complex IV assembly
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-DME-9865350] Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL - Drosophila melanogaster [Reaction:R-DME-9902096] COX18 inserts nascent MT-CO2 in COX20:TMEM77 - Drosophila melanogaster [Reaction:R-DME-9865412] TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC - Drosophila melanogaster [Reaction:R-DME-9865449] Metallochaperone inserts Cu2+ into MT-CO1 - Drosophila melanogaster [Reaction:R-DME-9865630] Metallochaperone inserts 2Cu2+ into MT-CO2 - Drosophila melanogaster [BlackBoxEvent:R-DME-9865663] MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-9864848] Complex IV assembly - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Complex IV assembly
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9864848
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-611105] Respiratory electron transport
(inferredTo)	[Pathway:R-HSA-9864848] Complex IV assembly

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