Reactome | N-WASP binds ARP2/3 and G-actin

Schema > Reaction > Entries

N-WASP binds ARP2/3 and G-actin Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10874698
displayName	N-WASP binds ARP2/3 and G-actin
eventOf	[Pathway:R-DME-3928662] EPHB-mediated forward signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3928595] N-WASP binds ARP2/3 and G-actin - Homo sapiens
input	[Complex:R-DME-1861670] ARP2/3 complex (ATP bound) [cytosol] [Complex:R-DME-201857] G-actin [cytosol] [Complex:R-DME-3928536] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	N-WASP binds ARP2/3 and G-actin
output	[Complex:R-DME-3928519] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane]
precedingEvent	[Reaction:R-DME-3928601] CDC42 and PIP2 bind WASL, activating it - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-3928595
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-3928662] EPHB-mediated forward signaling
(inferredTo)	[Reaction:R-HSA-3928595] N-WASP binds ARP2/3 and G-actin