Reactome | p120-RasGAP activates GTP hydrolysis on RAS, inactivating it

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p120-RasGAP activates GTP hydrolysis on RAS, inactivating it Show undefined attributes

catalystActivity	[CatalystActivity:10875108] GTPase activator activity of p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10875110
displayName	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
eventOf	[Pathway:R-DME-3928662] EPHB-mediated forward signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-4093339] p120-RasGAP activates GTP hydrolysis on RAS, inactivating it - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-DME-4093319] p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
output	[Complex:R-DME-4093320] p-EPHBs:EFNBs:RASA1:HRAS:GDP [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-DME-4093331] Ras:GTP binds p120-RasGAP - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-4093339
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-3928662] EPHB-mediated forward signaling
(inferredTo)	[Reaction:R-HSA-4093339] p120-RasGAP activates GTP hydrolysis on RAS, inactivating it

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