Reactome | CASP8 activity is inhibited

Schema > Pathway > Entries

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912670
displayName	CASP8 activity is inhibited
eventOf	[Pathway:R-DME-5675482] Regulation of necroptotic cell death - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:422917] negative regulation of endopeptidase activity
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-3465429] FLIP(S) and procaspase-8 form heterodimer - Drosophila melanogaster [Reaction:R-DME-5675456] FLIP(L) and procaspase-8 form heterodimer - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-5218900] CASP8 activity is inhibited - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	CASP8 activity is inhibited
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5218900
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-5675482] Regulation of necroptotic cell death
(inferredTo)	[Pathway:R-HSA-5218900] CASP8 activity is inhibited

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