Reactome | TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DME-3465352] DISC:procaspase-8:FLIP(S) [plasma membrane] - Drosophila melanogaster [Complex:R-DME-3371381] DISC:procaspase-8:FLIP(L) [plasma membrane] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-5675456] FLIP(L) and procaspase-8 form heterodimer - Drosophila melanogaster [Reaction:R-DME-3465429] FLIP(S) and procaspase-8 form heterodimer - Drosophila melanogaster [Reaction:R-DME-141159] TNF-mediated dimerization of procaspase-8 - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10837407
displayName	TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol]
hasComponent	[DefinedSet:R-DME-57031-6] Homologues of CASP8(1-479) [cytosol] [Complex:R-DME-140977] TRADD:TRAF2:RIPK1:FADD [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-140976] TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] - Homo sapiens [Complex:R-HSA-3465443] DISC:procaspase-8 [plasma membrane] - Homo sapiens
maxDepth	4
name	TRADD:TRAF2:RIP1:FADD:CASP8(1-479)
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-140976
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DME-5675456] FLIP(L) and procaspase-8 form heterodimer [Reaction:R-DME-3465429] FLIP(S) and procaspase-8 form heterodimer [Reaction:R-DME-141159] TNF-mediated dimerization of procaspase-8
(inferredTo)	[Complex:R-HSA-140976] TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] [Complex:R-HSA-3465443] DISC:procaspase-8 [plasma membrane]
(hasComponent)	[Complex:R-DME-3371381] DISC:procaspase-8:FLIP(L) [plasma membrane] [Complex:R-DME-3465352] DISC:procaspase-8:FLIP(S) [plasma membrane]