Reactome | PIP3 recruits AKT to the membrane

Schema > Reaction > Entries

PIP3 recruits AKT to the membrane Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10870872
displayName	PIP3 recruits AKT to the membrane
eventOf	[Pathway:R-DME-389357] CD28 dependent PI3K/Akt signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-198640] mTORC2 phosphorylates AKT at S473 - Drosophila melanogaster
goBiologicalProcess	[GO_BiologicalProcess:262252] activation of protein kinase B activity
inferredFrom	[Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane - Homo sapiens
input	[CandidateSet:R-DME-202088] AKT [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PIP3 recruits AKT to the membrane
output	[Complex:R-DME-2317329] AKT:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-DME-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-DME-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Drosophila melanogaster [Reaction:R-DME-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Drosophila melanogaster [Reaction:R-DME-2316434] PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-2317332
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-389357] CD28 dependent PI3K/Akt signaling [Pathway:R-DME-1257604] PIP3 activates AKT signaling
(precedingEvent)	[Reaction:R-DME-198640] mTORC2 phosphorylates AKT at S473
(inferredTo)	[Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane