Reactome | Destabilisation and degradation of AXN in the 'destruction complex'

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Destabilisation and degradation of AXN in the 'destruction complex' Show undefined attributes

authored	[InstanceEdit:386950] Williams, MG, 2006-07-26 16:49:12
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:205630] Williams, MG, 2006-06-28 10:48:14
dbId	209075
displayName	Destabilisation and degradation of AXN in the 'destruction complex'
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-209440] Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM - Drosophila melanogaster
figure	[Figure:210822] /figures/CDrosWing19.jpg
followingEvent	[Reaction:R-DME-209081] Disassembly of the destabilised 'destruction complex' - Drosophila melanogaster
input	[Complex:R-DME-206993] WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208103] Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity [LiteratureReference:208113] Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex [LiteratureReference:208273] Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Destabilisation and degradation of AXN in the 'destruction complex'
output	[Complex:R-DME-206837] WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane]
precedingEvent	[Reaction:R-DME-209112] Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM - Drosophila melanogaster
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386952] Nusse, Roel, 2008-01-19
schemaClass	BlackBoxEvent
species	[Species:56210] Drosophila melanogaster
stId	R-DME-209075
summation	[Summation:206539] Axin (AXN) is now destabilised and is degraded by an unknown...

Referrals

(hasEvent)	[Pathway:R-DME-209440] Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
(precedingEvent)	[Reaction:R-DME-209081] Disassembly of the destabilised 'destruction complex'

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