Reactome | Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR

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Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR Show undefined attributes

authored	[InstanceEdit:386950] Williams, MG, 2006-07-26 16:49:12
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:205630] Williams, MG, 2006-06-28 10:48:14
dbId	209120
displayName	Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-209440] Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM - Drosophila melanogaster
figure	[Figure:210823] /figures/CDrosWing17.jpg
followingEvent	[Reaction:R-DME-209112] Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM - Drosophila melanogaster
input	[EntityWithAccessionedSequence:R-DME-205749] DSH [cytosol] [Complex:R-DME-207028] Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] [Complex:R-DME-206613] WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208152] A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling [LiteratureReference:208147] A mechanism for Wnt coreceptor activation [LiteratureReference:208061] Signaling specificity by Frizzled receptors in Drosophila [LiteratureReference:208103] Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity [LiteratureReference:208391] Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP [LiteratureReference:208130] Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled [LiteratureReference:208316] Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR
output	[Complex:R-DME-206952] WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane]
precedingEvent	[Reaction:R-DME-209135] GISH further phosphorylates ARR in the receptor complex - Drosophila melanogaster [Reaction:R-DME-209109] Further phosphorylation of ARM by SGG - Drosophila melanogaster [Reaction:R-DME-209081] Disassembly of the destabilised 'destruction complex' - Drosophila melanogaster
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386952] Nusse, Roel, 2008-01-19
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-209120
summation	[Summation:206457] Phosphorylated Arrow (ARR) is recognised by Axin (AXN) which...

Referrals

(hasEvent)	[Pathway:R-DME-209440] Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
(precedingEvent)	[Reaction:R-DME-209112] Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM

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