Reactome | Autophosphorylated FU phosphorylates COS

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Autophosphorylated FU phosphorylates COS Show undefined attributes

authored	[InstanceEdit:386946] Williams, MG, 2006-12-07 16:49:12
catalystActivity	[CatalystActivity:208942] protein serine/threonine kinase activity of FU [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:205626] Williams, MG, 2006-12-08 11:30:45
dbId	209253
displayName	Autophosphorylated FU phosphorylates COS
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-216217] Activation of SMO - Drosophila melanogaster
figure	[Figure:216189] /figures/DrosHHB20.jpg
followingEvent	[Reaction:R-DME-216133] Dissociation of CI from COS - Drosophila melanogaster
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DME-216158] Phospho (9 sites) Act SMO:COS:CI:FU [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208191] Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2 [LiteratureReference:208117] Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog [LiteratureReference:208087] Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused [LiteratureReference:208029] The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells [LiteratureReference:216207] Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation [LiteratureReference:216259] Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling [LiteratureReference:216257] Hedgehog regulates smoothened activity by inducing a conformational switch [LiteratureReference:216205] Hedgehog signaling: a smoothened conformational switch
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autophosphorylated FU phosphorylates COS
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DME-206734] Phospho (9 sites) Act SMO:Phospho (2 sites) COS:CI:Phospho FU [plasma membrane]
precedingEvent	[Reaction:R-DME-216202] Phosphorylated SMO changes conformation and is activated - Drosophila melanogaster
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386945] Kalderon, D, 2008-03-17 11:00:25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-209253
summation	[Summation:206383] The Ser/Thr protein kinase, Fused (FU), is capable of autoph...

Referrals

(hasEvent)	[Pathway:R-DME-216217] Activation of SMO
(precedingEvent)	[Reaction:R-DME-216133] Dissociation of CI from COS