Reactome | Dissociation of CI from COS

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Dissociation of CI from COS Show undefined attributes

authored	[InstanceEdit:386946] Williams, MG, 2006-12-07 16:49:12
category	dissociation
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:216199] Williams, MG, 2008-03-11 15:41:17
dbId	216133
displayName	Dissociation of CI from COS
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-216119] Activation of CI - Drosophila melanogaster
figure	[Figure:216235] /figures/DrosHHB21.jpg
followingEvent	[Reaction:R-DME-209220] Liberation of CI from SU(FU) repression - Drosophila melanogaster [Reaction:R-DME-209163] CI transports from the cytosol to the nucleus - Drosophila melanogaster
input	[Complex:R-DME-206734] Phospho (9 sites) Act SMO:Phospho (2 sites) COS:CI:Phospho FU [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:216207] Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation [LiteratureReference:216259] Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of CI from COS
output	[EntityWithAccessionedSequence:R-DME-206046] CI [cytosol] [Complex:R-DME-206634] Phospho (9 sites) Act SMO:Phospho (2 sites) COS:Phospho FU [plasma membrane]
precedingEvent	[Reaction:R-DME-209253] Autophosphorylated FU phosphorylates COS - Drosophila melanogaster
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386945] Kalderon, D, 2008-03-17 11:00:25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-216133
summation	[Summation:216121] Coastal2 (COS) phosphorylated on Ser572 has reduced affinity...

Referrals

(precedingEvent)	[Reaction:R-DME-209163] CI transports from the cytosol to the nucleus [Reaction:R-DME-209220] Liberation of CI from SU(FU) repression
(hasEvent)	[Pathway:R-DME-216119] Activation of CI