Autophosphorylated FU phosphorylates COS

Stable Identifier
R-DME-209253
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Autophosphorylated FU phosphorylates COS
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The Ser/Thr protein kinase, Fused (FU), is capable of autophosphorylation and is proposed to be activated by phosphorylation on at least Thr158 and probably on other residues too. Costal2 (COS), bound to the phosphorylated transmembrane receptor Smoothened (SMO), is itself phosphorylated by FU at Ser572 and Ser931. Both FU and COS promote phosphorylation of SMO and its accumulation at the plasma membrane resulting in a positive feedback loop.
Literature References
PubMed ID Title Journal Year
18211840 Hedgehog signaling: a smoothened conformational switch

Kalderon, D

Curr Biol 2008
11495917 The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells

Fukumoto, T, Watanabe-Fukunaga, R, Fujisawa, K, Nagata, S, Fukunaga, R

J Biol Chem 2001
17671093 Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation

Liu, Y, Cao, X, Jiang, J, Jia, J

Genes Dev 2007
14636583 Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

Lum, L, Zhang, C, Oh, S, Mann, RK, von Kessler, DP, Taipale, J, Weis-Garcia, F, Gong, R, Wang, B, Beachy, PA

Mol Cell 2003
14523402 Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

Ruel, L, Rodriguez, R, Gallet, A, Lavenant-Staccini, L, Therond, PP

Nat Cell Biol 2003
11934882 Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused

Nybakken, KE, Turck, CW, Robbins, DJ, Bishop, JM

J Biol Chem 2002
17960137 Hedgehog regulates smoothened activity by inducing a conformational switch

Zhao, Y, Tong, C, Jiang, J

Nature 2007
17881487 Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling

Ruel, L, Gallet, A, Raisin, S, Truchi, A, Staccini-Lavenant, L, Cervantes, A, Therond, PP

Development 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of FU [cytosol]

Physical Entity
FU [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2006-12-07)
Reviewed
Kalderon, D  (2008-03-17)
Created
Williams, MG  (2006-12-08)
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