Reactome | HDAC1 [nucleoplasm]

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HDAC1 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-DME-9938417] HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] - Drosophila melanogaster [Complex:R-DME-9938417] HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] - Drosophila melanogaster [Complex:R-DME-9858619] HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] - Drosophila melanogaster [Complex:R-DME-9825719] HDAC1:SIN3A:HINT1:MITF-M:BCL2 gene [nucleoplasm] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-1227670] Recruitment of HDAC1 by p130 (RBL2) - Drosophila melanogaster [Reaction:R-DME-9858647] HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter - Drosophila melanogaster [Reaction:R-DME-1227671] Recruitment of HDAC1 by p107 (RBL1) - Drosophila melanogaster [Reaction:R-DME-9938418] HDAC1, 2 bind MTA1, 2, 3 and RBBP4,7 - Drosophila melanogaster [Reaction:R-DME-9938418] HDAC1, 2 bind MTA1, 2, 3 and RBBP4,7 - Drosophila melanogaster [Reaction:R-DME-8935732] RUNX1 binds SIN3A,(SIN3B) co-repressor - Drosophila melanogaster [Reaction:R-DME-9825754] HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10846726
displayName	HDAC1 [nucleoplasm]
endCoordinate	482
inDisease	false
inferredFrom	[DefinedSet:R-HSA-9938420] HDAC1,HDAC2 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-205021] HDAC1 [nucleoplasm] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-DME-205005] Histone deacetylase [nucleoplasm] - Drosophila melanogaster
name	HDAC1 HDAC1 Q94517
producedByEvent	[Reaction:R-DME-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Drosophila melanogaster [Reaction:R-DME-9009065] FOXA1 and GATA3 bind to CCND1 promoter - Drosophila melanogaster
referenceEntity	[ReferenceGeneProduct:uniprot:Q94517] UniProt:Q94517 HDAC1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:56210] Drosophila melanogaster
stId	R-DME-205021
startCoordinate	1

Referrals

(input)	[Reaction:R-DME-9825754] HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter [Reaction:R-DME-9858647] HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter [Reaction:R-DME-9938418] HDAC1, 2 bind MTA1, 2, 3 and RBBP4,7 [Reaction:R-DME-8935732] RUNX1 binds SIN3A,(SIN3B) co-repressor [Reaction:R-DME-1227671] Recruitment of HDAC1 by p107 (RBL1) [Reaction:R-DME-1227670] Recruitment of HDAC1 by p130 (RBL2)
(hasComponent)	[Complex:R-DME-9825719] HDAC1:SIN3A:HINT1:MITF-M:BCL2 gene [nucleoplasm] [Complex:R-DME-9858619] HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] [Complex:R-DME-9938417] HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4,RBBP7 [nucleoplasm] [Complex:R-DME-8935726] RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] [Complex:R-DME-9022428] HDAC1 homodimer [nucleoplasm] [Complex:R-DME-3299553] TLE1:HDAC1 [nucleoplasm] [Complex:R-DME-3772506] TLE:HDAC1 [nucleoplasm] [Complex:R-DME-1227668] HDAC1:RBL1:E2F4:TFDP1,TFDP2 [nucleoplasm] [Complex:R-DME-1227666] HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2 [nucleoplasm] [Complex:R-DME-9009060] CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] [Complex:R-DME-4657004] HDAC1:HDAC2 [nucleoplasm]
(activeUnit)	[CatalystActivity:10909964] histone deacetylase activity of NR2C2,NR2F2:ZNF827:NuRD:H4K5,H4K8 Ac telomeric chromatin [nucleoplasm]
(inferredTo)	[DefinedSet:R-HSA-9938420] HDAC1,HDAC2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-205021] HDAC1 [nucleoplasm]
(hasMember)	[DefinedSet:R-DME-205005] Histone deacetylase [nucleoplasm] [CandidateSet:R-DME-350066] HDAC [nucleoplasm]
(output)	[Reaction:R-DME-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF [Reaction:R-DME-9009065] FOXA1 and GATA3 bind to CCND1 promoter

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