Reactome | HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter

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HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10906566
displayName	HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter
eventOf	[Pathway:R-DME-9824594] Regulation of MITF-M-dependent genes involved in apoptosis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9825754] HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter - Homo sapiens
input	[EntityWithAccessionedSequence:R-DME-205021] HDAC1 [nucleoplasm] [Complex:R-DME-9825721] HINT1 dimer [nucleoplasm] [Complex:R-DME-9825715] MITF-M:BCL2 gene [nucleoplasm] [EntityWithAccessionedSequence:R-DME-351657] Sin3A [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter
output	[Complex:R-DME-9825719] HDAC1:SIN3A:HINT1:MITF-M:BCL2 gene [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9825754
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9824594] Regulation of MITF-M-dependent genes involved in apoptosis
(inferredTo)	[Reaction:R-HSA-9825754] HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter

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