Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

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Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Show undefined attributes

compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912272
displayName	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
eventOf	[Pathway:R-DME-983705] Signaling by the B Cell Receptor (BCR) - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Drosophila melanogaster [Reaction:R-DME-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Drosophila melanogaster [Reaction:R-DME-1168376] STIM1 oligomerizes - Drosophila melanogaster [Reaction:R-DME-2089927] STIM1 binds TRPC1 forming STIM1:TRPC1 complex - Drosophila melanogaster [Reaction:R-DME-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-983695
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-983705] Signaling by the B Cell Receptor (BCR)
(inferredTo)	[Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

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