Reactome | phospho-p-S218,S222-MAP2K1 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DME-109838] p-2S-MAP2K1:MAPK3 [cytosol] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-109857] MAP2K1 binds MAPK3 - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10835956
displayName	phospho-p-S218,S222-MAP2K1 [cytosol]
endCoordinate	393
hasModifiedResidue	[ModifiedResidue:10835953] O-phospho-L-serine at 218 (in Homo sapiens) [ModifiedResidue:10835954] O-phospho-L-serine at 222 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-109837] p-S218,S222-MAP2K1 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-DME-112336] MAP2K1 [cytosol] - Drosophila melanogaster
name	phospho-p-S218,S222-MAP2K1 Q24324
producedByEvent	[BlackBoxEvent:R-DME-109863] Dissociation of p-T,Y-MAPK3:MAP2K1 - Drosophila melanogaster
referenceEntity	[ReferenceGeneProduct:uniprot:Q24324] UniProt:Q24324 Dsor1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:56210] Drosophila melanogaster
stId	R-DME-109837
startCoordinate	2

(hasMember)	[DefinedSet:R-DME-112336] MAP2K1 [cytosol]
(output)	[BlackBoxEvent:R-DME-109863] Dissociation of p-T,Y-MAPK3:MAP2K1
(activeUnit)	[CatalystActivity:10835975] protein serine/threonine kinase activity of p-2S-MAP2K1:MAPK3 [cytosol]
(input)	[Reaction:R-DME-109857] MAP2K1 binds MAPK3
(hasComponent)	[Complex:R-DME-109838] p-2S-MAP2K1:MAPK3 [cytosol] [Complex:R-DME-109843] p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] [Complex:R-DME-5672703] p-S218,S222 MAP2K1 dimer [cytosol] [Complex:R-DME-5672705] p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-109837] p-S218,S222-MAP2K1 [cytosol]

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