Reactome | MAP2K1 binds MAPK3

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10835960
displayName	MAP2K1 binds MAPK3
eventOf	[Pathway:R-DME-110056] MAPK3 (ERK1) activation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-109860] MAP2K1 phosphorylates MAPK3 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-109857] MAP2K1 binds MAPK3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-DME-59284] MAPK3 [cytosol] [EntityWithAccessionedSequence:R-DME-109837] phospho-p-S218,S222-MAP2K1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MAP2K1 binds MAPK3
output	[Complex:R-DME-109838] p-2S-MAP2K1:MAPK3 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-109857
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-110056] MAPK3 (ERK1) activation
(precedingEvent)	[Reaction:R-DME-109860] MAP2K1 phosphorylates MAPK3
(inferredTo)	[Reaction:R-HSA-109857] MAP2K1 binds MAPK3

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