Reactome | Ub [nucleoplasm]

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Ub [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-DDI-6790516] Ub,SUMO,K63polyUb:XPC [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-8864169] Ub:E2 (UBA1 substrate) [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-6781851] Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] - Dictyostelium discoideum
consumedByEvent	[Reaction:R-DDI-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II - Dictyostelium discoideum [Reaction:R-DDI-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II - Dictyostelium discoideum [Reaction:R-DDI-69598] Ubiquitination of phosphorylated CDC25A - Dictyostelium discoideum [Reaction:R-DDI-69598] Ubiquitination of phosphorylated CDC25A - Dictyostelium discoideum [Reaction:R-DDI-69598] Ubiquitination of phosphorylated CDC25A - Dictyostelium discoideum [Reaction:R-DDI-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 - Dictyostelium discoideum [Reaction:R-DDI-6782943] UV-DDB ubiquitinates XPC - Dictyostelium discoideum [Reaction:R-DDI-3788724] Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 - Dictyostelium discoideum [Reaction:R-DDI-3788724] Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 - Dictyostelium discoideum [Reaction:R-DDI-68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin - Dictyostelium discoideum [Reaction:R-DDI-68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin - Dictyostelium discoideum [Reaction:R-DDI-68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin - Dictyostelium discoideum [Reaction:R-DDI-174057] Multiubiquitination of APC/C-associated Cdh1 - Dictyostelium discoideum [Reaction:R-DDI-174057] Multiubiquitination of APC/C-associated Cdh1 - Dictyostelium discoideum [Reaction:R-DDI-174057] Multiubiquitination of APC/C-associated Cdh1 - Dictyostelium discoideum [Reaction:R-DDI-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Dictyostelium discoideum [Reaction:R-DDI-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Dictyostelium discoideum [Reaction:R-DDI-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Dictyostelium discoideum [Reaction:R-DDI-1363331] Ubiquitination of p130 (RBL2) by SCF (Skp2) - Dictyostelium discoideum [Reaction:R-DDI-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Dictyostelium discoideum [Reaction:R-DDI-8852128] UBA1 adenylates ubiquitin in the nucleoplasm - Dictyostelium discoideum
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	10997110
displayName	Ub [nucleoplasm]
hasMember	[DefinedSet:R-DDI-939849-8] Homologues of RPS27A(1-76) [nucleoplasm] - Dictyostelium discoideum [DefinedSet:R-DDI-939870-8] Homologues of UBB(77-152) [nucleoplasm] - Dictyostelium discoideum [DefinedSet:R-DDI-939854-8] Homologues of UBB(153-228) [nucleoplasm] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-939871] ubqO [nucleoplasm] - Dictyostelium discoideum
inDisease	false
inferredFrom	[DefinedSet:R-HSA-68524] Ub [nucleoplasm] - Homo sapiens
maxDepth	3
name	Ub Ubiquitin UBIQ_HUMAN
producedByEvent	[Reaction:R-DDI-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Dictyostelium discoideum [BlackBoxEvent:R-DDI-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Dictyostelium discoideum [BlackBoxEvent:R-DDI-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Dictyostelium discoideum [BlackBoxEvent:R-DDI-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Dictyostelium discoideum [BlackBoxEvent:R-DDI-188191] APC/C:Cdh1-mediated degradation of Skp2 - Dictyostelium discoideum [BlackBoxEvent:R-DDI-188191] APC/C:Cdh1-mediated degradation of Skp2 - Dictyostelium discoideum [BlackBoxEvent:R-DDI-188191] APC/C:Cdh1-mediated degradation of Skp2 - Dictyostelium discoideum [Reaction:R-DDI-5690157] USP16,USP21 deubiquitinate Histone H2A - Dictyostelium discoideum [Reaction:R-DDI-5690080] USP3,SAGA deubiquitinate Histone H2A,H2B - Dictyostelium discoideum [Reaction:R-DDI-5691381] MYSM1 deubiquitinates Histone H2A - Dictyostelium discoideum [BlackBoxEvent:R-DDI-5635854] GLI2,3 are degraded by the proteasome - Dictyostelium discoideum [Reaction:R-DDI-6807118] USP7 deubiquitinates monoubiquitinated PTEN - Dictyostelium discoideum [Reaction:R-DDI-6807118] USP7 deubiquitinates monoubiquitinated PTEN - Dictyostelium discoideum [BlackBoxEvent:R-DDI-174058] Degradation of multiubiquitinated Cdh1 - Dictyostelium discoideum [BlackBoxEvent:R-DDI-174058] Degradation of multiubiquitinated Cdh1 - Dictyostelium discoideum [BlackBoxEvent:R-DDI-174058] Degradation of multiubiquitinated Cdh1 - Dictyostelium discoideum [BlackBoxEvent:R-DDI-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome - Dictyostelium discoideum [BlackBoxEvent:R-DDI-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome - Dictyostelium discoideum [BlackBoxEvent:R-DDI-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome - Dictyostelium discoideum
schemaClass	DefinedSet
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-68524

Referrals

(output)	[Reaction:R-DDI-5690157] USP16,USP21 deubiquitinate Histone H2A [Reaction:R-DDI-5690080] USP3,SAGA deubiquitinate Histone H2A,H2B [Reaction:R-DDI-5691381] MYSM1 deubiquitinates Histone H2A [BlackBoxEvent:R-DDI-5635854] GLI2,3 are degraded by the proteasome [Reaction:R-DDI-6782069] UVSSA:USP7 deubiquitinates ERCC6 [Reaction:R-DDI-6807118] USP7 deubiquitinates monoubiquitinated PTEN [BlackBoxEvent:R-DDI-69600] Proteolytic degradation of ubiquitinated-Cdc25A [BlackBoxEvent:R-DDI-188191] APC/C:Cdh1-mediated degradation of Skp2 [BlackBoxEvent:R-DDI-174058] Degradation of multiubiquitinated Cdh1 [BlackBoxEvent:R-DDI-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome
(hasComponent)	[Complex:R-DDI-8864169] Ub:E2 (UBA1 substrate) [nucleoplasm] [Complex:R-DDI-8852095] Ub-Cys632-UBA1 [nucleoplasm] [Complex:R-DDI-8942129] Ub:UBE2A,B [nucleoplasm] [Complex:R-DDI-8943019] Ub:UBE2N [nucleoplasm] [Complex:R-DDI-6781849] Ub:ERCC6 [nucleoplasm] [Complex:R-DDI-6781851] Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] [Complex:R-DDI-5696466] Ub:ERCC1 [nucleoplasm] [Complex:R-DDI-6790516] Ub,SUMO,K63polyUb:XPC [nucleoplasm] [Complex:R-DDI-6790462] Ub,SUMO:XPC [nucleoplasm] [Complex:R-DDI-6782951] Ub:XPC [nucleoplasm] [Complex:R-DDI-3788727] Ub-EHMT2 [nucleoplasm] [Complex:R-DDI-3788734] Ub-EHMT1 [nucleoplasm] [Complex:R-DDI-174068] multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] [Complex:R-DDI-1363324] Ub-p-T401,S672,1035-RBL2 [nucleoplasm] [Complex:R-DDI-187568] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] [Complex:R-DDI-5651984] MonoUb:K164-PCNA [nucleoplasm]
(input)	[Reaction:R-DDI-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus [Reaction:R-DDI-8852128] UBA1 adenylates ubiquitin in the nucleoplasm [Reaction:R-DDI-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 [Reaction:R-DDI-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II [Reaction:R-DDI-6782943] UV-DDB ubiquitinates XPC [Reaction:R-DDI-3788724] Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 [Reaction:R-DDI-68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin [Reaction:R-DDI-69598] Ubiquitination of phosphorylated CDC25A [Reaction:R-DDI-174057] Multiubiquitination of APC/C-associated Cdh1 [Reaction:R-DDI-9686969] APC/C:Cdh1 polyubiquitinates SKP2 [Reaction:R-DDI-1363331] Ubiquitination of p130 (RBL2) by SCF (Skp2)
(inferredTo)	[DefinedSet:R-HSA-68524] Ub [nucleoplasm]

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