Reactome | Multiubiquitination of APC/C-associated Cdh1

Schema > Reaction > Entries

Multiubiquitination of APC/C-associated Cdh1 Show undefined attributes

catalystActivity	[CatalystActivity:11004655] ubiquitin-protein transferase activity of phospho-Cdh1:phospho-APC/C complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11004657
displayName	Multiubiquitination of APC/C-associated Cdh1
eventOf	[Pathway:R-DDI-174084] Autodegradation of Cdh1 by Cdh1:APC/C - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DDI-174058] Degradation of multiubiquitinated Cdh1 - Dictyostelium discoideum
goBiologicalProcess	[GO_BiologicalProcess:7441] ubiquitin-dependent protein catabolic process
inferredFrom	[Reaction:R-HSA-174057] Multiubiquitination of APC/C-associated Cdh1 - Homo sapiens
input	[Complex:R-DDI-174167] phospho-Cdh1:phospho-APC/C complex [nucleoplasm] 3 × [DefinedSet:R-DDI-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Multiubiquitination of APC/C-associated Cdh1
output	[Complex:R-DDI-174068] multiubiquitinated Cdh1 associated with APC/C [nucleoplasm]
precedingEvent	[Reaction:R-DDI-174195] Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-174057
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-174084] Autodegradation of Cdh1 by Cdh1:APC/C
(precedingEvent)	[BlackBoxEvent:R-DDI-174058] Degradation of multiubiquitinated Cdh1
(inferredTo)	[Reaction:R-HSA-174057] Multiubiquitination of APC/C-associated Cdh1

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