Reactome | ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II

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ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II Show undefined attributes

catalystActivity	[CatalystActivity:11030762] ubiquitin protein ligase activity of Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11030764
displayName	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
eventOf	[Pathway:R-DDI-6781823] Formation of TC-NER Pre-Incision Complex - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II - Homo sapiens
input	[Complex:R-DDI-6781839] Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] 2 × [DefinedSet:R-DDI-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
output	[Complex:R-DDI-6781866] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm]
precedingEvent	[Reaction:R-DDI-6781833] ERCC8 (CSA) binds stalled RNA Pol II - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-6781867
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-6781823] Formation of TC-NER Pre-Incision Complex
(inferredTo)	[Reaction:R-HSA-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II

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