Reactome | phospho-BRIP1 [nucleoplasm]

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-DDI-5685989] 3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-5685317] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-9980022] ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-5686616] ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] - Dictyostelium discoideum
consumedByEvent	[Reaction:R-DDI-5685985] EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment - Dictyostelium discoideum
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11027759
displayName	phospho-BRIP1 [nucleoplasm]
endCoordinate	1249
hasModifiedResidue	[ModifiedResidue:11027756] O-phospho-L-serine at 990 (in Homo sapiens) [ModifiedResidue:11027757] N6-acetyl-L-lysine at 1249 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-5687710] p-S990,Ac-K1249-BRIP1 [nucleoplasm] - Homo sapiens
maxDepth	1
name	phospho-BRIP1 p-S990,Ac-K1249-BRIP1 Q54LI7
referenceEntity	[ReferenceGeneProduct:uniprot:Q54LI7] UniProt:Q54LI7
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5687710
startCoordinate	1

(hasComponent)	[Complex:R-DDI-9980022] ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Complex:R-DDI-5686616] ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Complex:R-DDI-5685989] 3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] [Complex:R-DDI-5685317] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] [Complex:R-DDI-5684128] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm]
(input)	[Reaction:R-DDI-5685985] EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-5687710] p-S990,Ac-K1249-BRIP1 [nucleoplasm]

phospho-BRIP1 [nucleoplasm] Show undefined attributes

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