Reactome | EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment

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EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11027799
displayName	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
eventOf	[Pathway:R-DDI-5693607] Processing of DNA double-strand break ends - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-5685994] Long-range resection of DNA DSBs by EXO1 or DNA2 - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-5685985] EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment - Homo sapiens
input	[Complex:R-DDI-5685983] 3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] [DefinedSet:R-DDI-5685980] EXO1,DNA2:BLM,WRN [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-5687710] phospho-BRIP1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
output	[Complex:R-DDI-5685989] 3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm]
precedingEvent	[Reaction:R-DDI-5693608] Initial resection of double-strand break ends - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5685985
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-5693607] Processing of DNA double-strand break ends
(precedingEvent)	[Reaction:R-DDI-5685994] Long-range resection of DNA DSBs by EXO1 or DNA2
(inferredTo)	[Reaction:R-HSA-5685985] EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment

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